Praziquantel is an effective anthelmintic medication widely used for the treatment of schistosomiasis, a parasitic disease caused by Schistosoma species. These blood flukes infect humans when they come into contact with contaminated freshwater, where the larvae penetrate the skin and eventually settle in blood vessels. The most common types affecting humans include Schistosoma mansoni, S. haematobium, and S. japonicum.
Praziquantel works by increasing the permeability of the parasite’s cell membranes to calcium ions, causing intense contractions and paralysis of the worms. This leads to their dislodgment from blood vessel walls and eventual destruction by the host’s immune system. The drug is effective against both adult and some immature forms of the parasite. Medzsupplier is Praziquantel Wholesale Supplier, Wholesaler and exporter.
The tablet is usually taken orally in a single-day regimen, with the dose adjusted according to body weight and the type of Schistosoma infection. Commonly, treatment is given as two or three divided doses in one day. It is essential to take the medication with food to enhance absorption.
Most patients tolerate praziquantel well. Side effects are generally mild and may include dizziness, headache, abdominal discomfort, or nausea. In rare cases, allergic reactions or liver enzyme elevations may occur.
Praziquantel is listed as an essential medicine by the World Health Organization due to its proven efficacy, safety profile, and importance in global efforts to control neglected tropical diseases. In endemic areas, mass drug administration campaigns are often employed to reduce infection rates and prevent long-term complications like liver fibrosis, bladder damage, or infertility.
In summary, praziquantel plays a critical role in the effective treatment of schistosomiasis, helping to reduce the burden of this serious parasitic disease across affected regions.
